Evaluations of Biomarker Status Changes between Primary and Recurrent Tumor Tissue Samples in Breast Cancer Patients

Table 1

Patient demographics and clinical characteristics.

Characteristics	Number ()	Percentage
At time of initial diagnosis
Age (median (IQR))	44	(38–53)
Menopause status
Pre-menopause	38	56.7%
Post-menopause	29	43.3%
Stage at diagnosis
0	2	3.0%
I	11	16.4%
II	27	40.3%
III	27	30.3%
Pathological types
Ductal	54	80.6%
Lobular	6	9.0%
Other	7	10.4%
Therapy
Chemotherapy	53	79.1%
Endocrine therapy	37	55.2%
Trastuzumab	5	7.5%
At time of recurrence
Duration from primary to recurrent disease
<24 months	17	25.4%
24–36 months	8	11.9%
>36–60 months	28	41.8%
>60 months	14	20.9%
Locoregional recurrence	48	71.6%
Chest wall	17	25.4%
Regional lymph nodes	36	53.7%
Distant metastasis
Lung	15	22.4%
Liver	5	7.5%
Bone	10	14.9%
Mediastinal lymph node	9	13.4%
Data: distant metastasis/other	5	7.5%
Site of biopsy
Locoregional	45	67.2%
Lung	8	11.9%
Liver	4	6.0%
Bone	2	3.0%
Brain	1	1.5%
Mediastinal lymph node	1	1.5%
Others	6	9.0%