Cell Type Specific Expression of Toll-Like Receptors in Human Brains and Implications in Alzheimer’s Disease

Figure 1

The potential role of neuroinflammation in Alzheimer’s disease. Chronic exposure to inflammatory stimuli such as amyloid beta (Aβ) stimulates neurotoxic activation of microglia and astrocytes, triggering the release of proinflammatory cytokines and reactive oxygen species, promoting degeneration of neurons.