Cell Type Specific Expression of Toll-Like Receptors in Human Brains and Implications in Alzheimer’s Disease

Table 2

Overview of TLR expression in various AD or LPS studies compared to a healthy control. Data from database (http://research-pub.gene.com/BrainMyeloidLandscape).

Receptor	Mouse	Mouse	Human	LPS treatment
	cell studies	Whole tissue	Whole tissue	^1Microglia^2Cortical
TLR 1	Up	Up	Not significant	^1Up	^2Up
TLR 2	Up	Up	Up	^1Up	^2Up
TLR 3	Down	Up	Up	^1Down	^2Up
TLR 4	Down	Up	Up	^1Down	^2Down
TLR 5	Down	Up	Up	^1Down	^2Down
TLR 6	Down	Up	Up	^1Up	^2Up
TLR 7	Not significant	Up	Up	^1Down	^2Up
TLR 8	Not significant	Not significant	Up	^1Up	^2Up
TLR 9	Down	Up	Up	^1Up	^2Same
TLR 10	Not tested	Not tested	Up	Not tested