A High Throughput HPLC-MS/MS Method for Antihypertensive Drugs Determination in Plasma and Its Application on Pharmacokinetic Interaction Study with Shuxuetong Injection in Rats

Table 1

Mass spectra properties of the analytes and IS.

Compounds	Precursor Ion (m/z)	Product Ion (m/z)	Frag. (V)	C.E. (V)
metoprolol tartrate	268.1	121.0	95	20
hydrochlorothiazide	295.8	205.2	115	-16
nifedipine	347.1	254.1	91	14
valsartan	434.2	179.0	123	-20
methyclothiazide(IS)	357.9	321.8	135	-3