A High Throughput HPLC-MS/MS Method for Antihypertensive Drugs Determination in Plasma and Its Application on Pharmacokinetic Interaction Study with Shuxuetong Injection in Rats

Table 6

Pharmacokinetic parameters of the analytes in different groups (n = 6).

Compounds	(ng/mL)	t1/2; (h)	AUC(0-tn); (h·ng/mL)	AUC(0-∞); (h·ng/mL)	(h)	Ke; (1/h)
metoprolol tartrate
group A	1068.55 ± 330.39	0.84 ± 0.28	1621.21 ± 464.32	1628.06 ± 454.86	0.36 ± 0.15	0.90 ± 0.29
group B	2277.29 ± 240.30	1.06 ± 0.81	3787.97 ± 283.12	3829.12 ± 310.13	0.54 ± 0.25	0.88 ± 0.39
group C	3045.11 ± 424.22	2.16 ± 0.84	5975.49 ± 776.71	6020.93 ± 719.30	0.50 ± 0.00	0.42 ± 0.31
hydrochlorothiazide
group A	1515.75 ± 235.11	3.26 ± 0.77	10091.55 ± 1285.15	10756.45 ± 1664.18	1.63 ± 1.24	0.23 ± 0.07
group B	2292.22 ± 209.37	2.68 ± 0.31	10687.69 ± 950.21	11020.65 ± 939.29	0.79 ± 0.19	0.26 ± 0.03
group C	1406.19 ± 248.74	2.52 ± 0.31	8479.60 ± 1243.01	8616.52 ± 1265.25	2.00 ± 0.00	0.28 ± 0.03
nifedipine
group A	205.38 ± 73.57	4.45 ± 2.18	1914.09 ± 350.20	2090.41 ± 514.96	3.33 ± 1.03	0.20 ± 0.11
group B	554.60 ± 126.68	2.81 ± 0.85	4217.35 ± 1072.42	4289.90 ± 1100.45	3.33 ± 1.03	0.27 ± 0.08
group C	819.06 ± 146.92	3.12 ± 1.05	5706.47 ± 485.23	5810.56 ± 458.46	2.67 ± 1.51	0.25 ± 0.10
valsartan
group A	3669.94 ± 720.62	2.97 ± 1.43	19563.78 ± 9850.62	21861.22 ± 12174.60	0.46 ± 0.29	0.27 ± 0.11
group B	3458.54 ± 324.28	2.47 ± 0.80	15146.64 ± 4814.24	17246.65 ± 6629.68	0.46 ± 0.10	0.31 ± 0.13
group C	4385.92 ± 1246.27	3.40 ± 0.88	20302.97 ± 6783.12	23030.31 ± 7186.54	0.24 ± 0.03	0.21 ± 0.04