Research Article

Delayed Rectifier K+-Channel Is a Novel Therapeutic Target for Interstitial Renal Fibrosis in Rats with Unilateral Ureteral Obstruction

Figure 5

Markers for leukocytes and their proliferation in margatoxin-untreated and margatoxin-treated UUO rat kidneys. (a) Hematoxylin and eosin (H&E) staining and immunohistochemistry using antibodies for CD3 and ED-1 (brown) in margatoxin- (Mgx-) untreated (A, C, E) and margatoxin-treated (B, D, F) UUO rat kidneys. High-power views of cortex. Magnification: ×60. CD3-positive (G) and ED-1-positive (H) cells were counted in high-power views of the cortical interstitium. (b) Immunohistochemistry using antibody for Ki-67 (brown) in margatoxin- (Mgx-) untreated (A) and margatoxin-treated (B) UUO rat kidneys. High-power views of cortical interstitium. Magnification: ×60. (C) Ki-67-positive cells were counted in high-power views of the cortical interstitium. versus margatoxin-untreated UUO rats. Values are means ± SEM (n = 6). Differences were analyzed by ANOVA followed by Dunnett’s or Student’s t test.
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