Effects of Pyrene on Human Liver HepG2 Cells: Cytotoxicity, Oxidative Stress, and Transcriptomic Changes in Xenobiotic Metabolizing Enzymes and Inflammatory Markers with Protection Trial Using Lycopene
Changes in mRNA expressions of xenobiotic-metabolizing enzymes in HepG2 cells exposed to pyrene. The effects of pyrene (0–50 n) on (a) CYP1A1, (b) CYP1A2, (c) CYP1B1, (d) UGT1A6, (e) GSTA1, (f) NQO1, (g) MDR1, and (h) MRP2 mRNA expression as determined by real-time RT-PCR. Data are presented as mean ± SD (n = 6). Columns with different superscript letters are significantly different from each other ().
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