Glutathione Peroxidase 1 Promotes NSCLC Resistance to Cisplatin via ROS-Induced Activation of PI3K/AKT Pathway

Figure 2

Increased expression of GPX1 promotes cisplatin resistance in NSCLC cells. ((a), (b)) To confirm the transfection efficiency, we used quantitative RT-PCR (a) and western blotting (b). Decreasing ((c) and (d)) or increasing ((e) and (f)) GPX1 expression influenced the cisplatin resistance in NSCLC cells. Reduced GPX1 expression downregulates cisplatin resistance, and increased GPX1 expression enhances cisplatin resistance (<0.05). Highly significant effects were observed at cisplatin concentrations of 2.5 and 5 μmol/L.

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