Glutathione Peroxidase 1 Promotes NSCLC Resistance to Cisplatin via ROS-Induced Activation of PI3K/AKT Pathway

Figure 3

Increased GPX1 expression reduced intracellular ROS accumulation in NSCLC cells. The H460 (a) and H1650 (b) were transfected with GPX1 expression vector, and GEO mean value was detected by a flow cytometer after cells were treated with different concentrations of cisplatin for 72 h in culture. Along with the increased concentrations of cisplatin, intracellular ROS (GEO mean) in GPX1 vector transfected cells decreased as compared to empty vector transfected control cells ((c) and (d)). The difference of intracellular ROS levels between GPX1 vector and empty vector transfected cells is statistically significant (P<0.05).

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