Imperatorin Suppresses Anaphylactic Reaction and IgE-Mediated Allergic Responses by Inhibiting Multiple Steps of FceRI Signaling in Mast Cells: IMP Alleviates Allergic Responses in PCA

<div>Effects of IMP on activation of AKT and MAPK signaling pathways in RBL-2H3 cells. RBL-2H3 cells were divided into the Con, IgE+Ag, and IgE+Ag+IMP groups. RBL-2H3 cells were stimulated with 10 μg/ml anti-DNP IgE for 6 h and challenged with 100 ng/ml DNP-HAS, in the absence or presence of IMP (10, 20, and 40 μM, respectively). Levels of Akt, p38, JNK, and ERK were detected by Western blot analysis. Compared with the Con group, ∗P&lt;0.05, ∗∗P&lt;0.01; compared with the IgE+Ag group, #P&lt;0.05, ##P&lt;0.01.</div>

BioMed Research International

fig5

Figure 5

Figure 5: Imperatorin Suppresses Anaphylactic Reaction and IgE-Mediated Allergic Responses by Inhibiting Multiple Steps of FceRI Signaling in Mast Cells: IMP Alleviates Allergic Responses in PCA 

Figure 5 | Imperatorin Suppresses Anaphylactic Reaction and IgE-Mediated Allergic Responses by Inhibiting Multiple Steps of FceRI Signaling in Mast Cells: IMP Alleviates Allergic Responses in PCA 