Research Article

Wnt Signaling Protects against Paclitaxel-Induced Spiral Ganglion Neuron Damage in the Mouse Cochlea In Vitro

Figure 1

Paclitaxel treatment damaged SGNs. (a) The diagram of the assay for (b) and (c). The middle turn cochleae and SGN explants from P3 C57BL/6 WT mice were cultured and incubated with different concentrations of paclitaxel (10 μM, 20 μM, or 30 μM) for 48 h and then used for immunostaining. (b and c) Immunofluorescence revealed paclitaxel led to a degenerative change and reduction of SGNs in a dose-dependent manner. , vs. control group.