Prognostic Impact of Adenosine Receptor 2 (A2aR) and Programmed Cell Death Ligand 1 (PD-L1) Expression in Colorectal Cancer

Table 5

Multivariate analysis of prognostic variables in 204 colorectal cancer patients (p-value was performed using Cox proportional hazard model).

Characteristic	N=204		Hazard ratio	95% CI	p-value
Distant metastasis		2.718	15.151	6.502-35.303	<0.001
No	185
Yes	19
TNM stage		1.434	4.195	1.869-9.415	0.001
I/II	106
III/IV	98
PD-L1		0.649	1.914	1.031-3.553	0.040
Negative	120
Positive	84
A2aR		0.875	2.400	1.264-4.558	0.007
Negative	96
Positive	108

Notes: potential prognostic factors were selected based on univariate results (p<0.05) to conduct multivariate analysis using Cox proportional hazards regression models. Positive PD-L1 status (HR=1.914, 95% CI:1.031-3.553, p=0.040), positive A2aR expression (HR=2.400, 95% CI: 1.264-4.558, p=0.007), distant metastasis (HR=15.151, 95% CI: 6.502-35.303, p<0.001), and TNM stage (HR=4.195, 95% CI: 1.869-9.415, p=0.001) could be independent prognostic predictors for colorectal cancer patients.