Integrating Bacterial Identification and Susceptibility Testing: A Simple and Rapid Approach to Reduce the Turnaround Time in the Management of Blood Cultures
Table 2
Antimicrobial susceptibility testing performance of rapid antimicrobial susceptibility testing (rAST) compared with the standard method (sAST).
Antimicrobial agents
CA (%)
VME (%)
ME (%)
mE (%)
Kappa score
GN
Amikacin
98.3
1 (0.5)
1 (0.5)
0 (0)
0.96
Amoxicillin-clavulanate
98.1
0 (0)
1 (0.5)
2 (1.1)
0.95
Ampicillin
97.0
0 (0)
1 (0.5)
4 (2.2)
0.85
Ampicillin-sulbactam
97.8
0 (0)
1 (0.5)
8 (4.4)
0.93
Cefepime
96.9
2 (1.1)
1 (0.5)
1 (0.5)
0.97
Ceftazidime
97.2
1 (0.5)
1 (0.5)
2 (1.1)
0.96
Cefuroxime
97.2
1 (0.5)
1 (0.5)
2 (1.1)
0.93
Ciprofloxacin
97.8
1 (0.5)
1 (0.5)
1 (0.5)
0.94
Gentamicin
97.5
2 (1.1)
1 (0.5)
0 (0)
0.95
Meropenem
98.3
1 (0.5)
1 (0.5)
0 (0)
0.97
Piperacillin-tazobactam
93.0
4 (2.2)
1 (0.5)
5 (2.7)
0.90
Trimethoprim-sulfamethoxazole
98.3
2 (1.1)
0 (0)
0 (0)
0.99
Total
97.7
15 (0.7)
10 (0.5)
25 (1.1)
GP
Clarithromycin
95.5
3 (1.8)
1 (0.6)
1 (0.6)
0.91
Erythromycin
99.0
0 (0)
1 (0.6)
0 (0)
0.99
Clindamycin
98.0
2 (1.2)
0 (0)
0 (0)
0.87
Doxycycline
100
0 (0)
0 (0)
0 (0)
0.91
Rifampicin
100
0 (0)
0 (0)
0 (0)
0.99
Gentamicin
96.6
1 (0.6)
0 (0)
4 (2.4)
0.99
Levofloxacin
91.9
1 (0.6)
6 (3.7)
2 (91.2)
0.91
Oxacillin
97.4
0 (0)
2 (1.2)
1 (0.6)
0.95
Trimethoprim-sulfamethoxazole
95.6
0 (0)
2 (1.2)
4 (2.4)
0.91
Total
98
7 (0.5)
11 (0.7)
12 (0.8)
Categorical agreement (CA), very major error (VME), major error (ME), and minor error (mE) per antibiotic agents used for Gram negative (GN) and Gram positive (GP). Kappa scores of the 2196 antimicrobial agent determinations result of rAST for Gram-negative bacteria isolates and 1476 antimicrobial agent determinations result of rAST for Gram-positive bacteria isolates.
