Research Article

Neoantigens Derived from Recurrently Mutated Genes as Potential Immunotherapy Targets for Gastric Cancer

Table 2

The list of mutations of six recurrently mutated genes, mutation position, number of patients affected, corresponding patient HLA allele, number of predicted neoantigens, and number of patients affected in ICGC project.

GeneMutation in Protein PositionNumber of patients affected in this study (total 32)Patient HLA AlleleNumber of predicted neoantigens Number of patients affected in ICGC (total 12,198)

BRCA2I27V1B58:01
C03:02
C08:01
60
S37L1B15:02
B58:01
C03:02
61
V144F1B15:02
C03:02
50
Q147R1A33:0320
D156E1A11:0110
N289H1A02:01
C03:02
53
T2542M1C14:0220

FAT4Q453L1A02:01
C03:02
125
V462E1B40:01
B58:01
C03:02
110
D598Y1A02:01
B15:01
50
A807V1A02:01
B40:01
B58:01
C03:02
136

GNAQD95Y1A24:10
B18:02
B39:01
C07:02
80
T96S3A02:01
A03:01
A11:01
B15:01
B39:01
2510

LRP1BH4368Q1A11:0210
L1995M1C03:0410
R3026S1A03:01
B15:01
30
R4062K1A11:01
A33:03
C03:02
80
T2206I1A02:0110

PIK3CAG106C1A03:01
A11:01
20
H1047Y1B15:0118
V344M1A03:01
A11:01
C14:02
45

PREX2E1428K1A30:0120
H895Q1B15:01
C03:03
30
Q102H1B15:0110
S1488L1A02:01
A33:03
B40:01
C07:02
100