Irradiated Bladder Cancer Cells Expressing both GM-CSF and IL-21 versus Either GM-CSF or IL-21 Alone as Tumor Vaccine in a Mouse Xenograft Model

GM-CSF/IL-21 enhanced the infiltration by CD4+ and CD8+ T cells and upregulated IL-12 and IFN-γ (P &lt; 0.05). On day 19 after tumor injection, subcutaneous tumor tissue was collected from each group, and CD4+ and CD8+ T cells were detected by histology and immunohistochemistry (P &lt; 0.05). Magnification, 200×.

BioMed Research International

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Figure 4

Figure 4: Irradiated Bladder Cancer Cells Expressing both GM-CSF and IL-21 versus Either GM-CSF or IL-21 Alone as Tumor Vaccine in a Mouse Xenograft Model 

Figure 4 | Irradiated Bladder Cancer Cells Expressing both GM-CSF and IL-21 versus Either GM-CSF or IL-21 Alone as Tumor Vaccine in a Mouse Xenograft Model 