Network Analyses of Differentially Expressed Genes in Osteoarthritis to Identify Hub Genes

Table 2

The significantly enriched analysis of DEGs in osteoarthritis.

Expression	Category	Term	Description	Gene Count	P Value
UP-DEGs	BP	GO:0006954	inflammatory response	19	1.21E-13
	BP	GO:0007267	cell-cell signaling	11	3.03E-07
	BP	GO:0070098	chemokine-mediated signaling pathway	6	2.07E-05
	BP	GO:0006935	chemotaxis	7	2.34E-05
	BP	GO:0006955	immune response	11	2.71E-05
	CC	GO:0005615	extracellular space	25	1.66E-09
	CC	GO:0005576	extracellular region	27	2.28E-09
	CC	GO:0005578	proteinaceous extracellular matrix	6	0.006499621
	CC	GO:0016323	basolateral plasma membrane	4	0.044790466
	CC	GO:0031988	membrane-bounded vesicle	2	0.05975494
	MF	GO:0008009	chemokine activity	5	6.54E-05
	MF	GO:0045236	CXCR chemokine receptor binding	3	6.87E-04
	MF	GO:0050786	RAGE receptor binding	3	0.001043791
	MF	GO:0005540	hyaluronic acid binding	3	0.004638666
	MF	GO:0005125	cytokine activity	5	0.007811921
DOWN-DEGs	BP	GO:0006629	lipid metabolic process	5	0.001123386
	BP	GO:0050873	brown fat cell differentiation	3	0.003912643
	BP	GO:0010890	positive regulation of sequestering of triglyceride	2	0.020252031
	BP	GO:0010642	negative regulation of platelet-derived	2	0.020252031
			growth factor receptor signaling pathway
	BP	GO:0042593	glucose homeostasis	3	0.035075126
	CC	GO:0005811	lipid particle	7	6.93E-08
	CC	GO:0005739	mitochondrion	11	0.009807547
	CC	GO:0070062	extracellular exosome	16	0.031369825
	CC	GO:0005576	extracellular region	11	0.032718894
	CC	GO:0005615	extracellular space	9	0.067564494
	MF	GO:0042803	protein homodimerization activity	7	0.016759119
	MF	GO:0008144	drug binding	3	0.01974095