Acute and Subacute Toxicity Studies of the Ethyl Acetate Soluble Proanthocyanidins of the Immature Inflorescence of Cocos nucifera L. in Female Wistar Rats

Table 5

Effect of EASPA on serum biochemical parameters in the subacute toxicity study.

Biochemical parameters	Unit	Control	1.75 mg/kg	3.5 mg/kg	7 mg/kg	14 mg/kg
ALP	U/L	226.83 ±15.14	246.50 ± 9.75	245.17 ± 3.00	244.00 ± 3.96	260.83 ± 5.59
ALT	U/L	72.31 ± 3.26	68.35 ± 4.05	70.08 ± 10.00	74.90 ± 12.23	64.55 ± 8.07
Glucose	mg/dL	75.24 ± 10.03	80.9 ± 10.28	83.12 ± 22.28	74.38 ± 7.48	82.06 ± 5.05
Cholesterol	mg/dL	62.95 ± 3.56	63.51 ± 1.78	64.16 ± 2.13	55.03 ± 0.99	60.08 ± 0.77
Urea	mmol/L	7.03 ± 0.48	5.91 ± 0.16	6.03 ± 0.14	6.32 ± 0.23	5.95 ± 0.23

Values are expressed as a mean ± SEM ( and ). (ALP: Serum alkaline phosphatase; ALT: serum alanine aminotransferase.)