Positive Correlation between Activated CypA/CD147 Signaling and MMP-9 Expression in Mice Inflammatory Periapical Lesion

Figure 2

(a) The immunohistochemistry staining of TRAP, CypA, CD147, and MMP-9 on day 7, day 21, day 35, and day 49 in mice periapical lesions (original magnification, 400; scale bar = 50 μm). The dark brown cells represented the positive cells. Along with the exacerbation of the inflammatory reaction in periapical lesion, the positive cells of TRAP, CypA, CD147, and MMP-9 increased until on day 35 and all decreased on day 49. The distribution of TRAP, CypA, and CD147 positive cells was mostly in osteoclast-like cells adjacent to the bone resorption lacuna (red arrows). (b) The number of TRAP, CypA, CD147, and MMP-9 positive cells in periapical lesions. (c) The correlation between CypA⁺ and TRAP⁺, MMP-9⁺, and CD147⁺ cells in mice periapical lesions, respectively. (d) The colocalization of CypA and CD147 in seriate sections of periapical lesions. The majority of the positive cells for CypA/CD147 were multinucleated osteoclast-like cells showed by red arrows.

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