Tubulointerstitial Infiltration of M2 Macrophages in Henoch-Schönlein Purpura Nephritis Indicates the Presence of Glomerular Crescents and Bad Clinical Parameters

Table 3

Comparison of M1 and M2 macrophage counts according to patient groups based on GFR and ISKDC classification.

Factors

ECr

Non-ECr^a

P

CRF

Non-CRF

P

Class I-II

Class III-IV

P

Crescents

No crescents

P

(n=17) Mean±SD

(n=32) Mean±SD

(n=13) Mean±SD

(n=36) Mean±SD

(n=25) Mean±SD

(n=24) Mean±SD

(n=20) Mean±SD

(n=27) Mean±SD

Glomeruli

M1

2.3±4.4

0.3±0.8

0.088

2.5±5.0

0.4±0.9

0.156

0.4±0.9

1.7±3.8

0.115

2.0±4.1

0.4±0.8

0.099

M2

8.7±14.7

4.1±9.1

0.176

9.7±16.6

4.2±8.7

0.274

3.4±10.3

8.0±12.3

0.164

9.2±13.1

3.4±9.9

0.094

Tubulointerstitium

M1

1.5±2.8

0.1±0.2

0.055

0.9±1.5

0.5±1.9

0.468

0.2±0.4

1.0±2.5

0.118

1.2±2.7

0.2±0.3

0.089

M2

81.1±44.7

37.4±24.0

0.001

86.4±33.9

40.4±32.6

<0.001

35.8±24.5

70.1±42.9

0.002

73.7±41.8

35.7±23.3

0.001

Definition of elevation of creatinine (ECr) is the status of high creatinine ≥1.0 mg/dl.
Definition of chronic renal failure (CRF) is the status of low GFR, which is below 60 ml/min/1.73 m² for more than 3 months.
Independent two-sample t-test for continuous variables; P-value <0.05 was considered statistically significant.
GFR, glomerular filtration rate; ISKDC, International Study of Kidney Disease in Children.