Multifunctional Pharmaceutical Effects of the Antibiotic Daptomycin

Figure 2

The action mechanism of DAP combined with β-lactams. (a) Penicillin binding protein 1 (PBP1) activity is related to DAP-induced metabolic stress, and it forms an adaptive response to DAP-mediated surface injury. (b) Targeting inactivation of PBP1 makes DAP-nonsusceptible S. aureus strains revert to subsequent DAP-susceptible strains, which enhances the binding of DAP with cell membrane and then induces cell death.