Multifunctional Pharmaceutical Effects of the Antibiotic Daptomycin

Table 2

DAP combination therapies against DNS strains.

DAP combination	Strains	For DNS strains	Mechanisms	Activity	Refs
DAP+Oxacillin	MRSA	Syn	Changes in peptidoglycan insertion; Reduction in membrane amounts of PBP2a	In vivo, In vitro	[58]
DAP+Ceftaroline	MRSA	Syn	Enhance the binding of DAP	In vitro	[61, 62]
DAP+Gentamicin	MRSA	Syn	Not mentioned	In vitro	[66]
DAP+Fosfomycin	VRE	Syn	Reduction in cell surface charge	In vitro	[69]
DAP+Ampicillin	VRE	Syn	Reduction in cell surface charge	In vitro	[59]
DAP+Ceftriaxone	Streptococcus mitis	Syn	Prevent DAP resistance emergence	In vitro	[63]

DNS, DAP-nonsusceptible.
Syn, synergy.
PBP2a, penicillin binding protein 2a.