Review Article

Bloodletting Therapy for Patients with Chronic Urticaria: A Systematic Review and Meta-Analysis

Table 1

The characteristics of included trials.

ReferenceDesignComparisonsBloodletting regimen Treatment frequency and durationOutcomes

Gan 2018 [25]Parallel, 2 armsbloodletting, 30
cetirizine, 30
disposable syringe needle with cupping;
Geshu (BL 17), Feishu (BL 13), Pishu (BL 20)
every other day; a total of 4 timesresponse rate;
recurrence rate;
adverse events

Shi 2016 [26]Parallel, 2 armsbloodletting, 33
cetirizine, 33
triangle-edged needle with cupping;
Feishu (BL 13), Pishu (BL 20), Quchi (LI 11), Dazhui (DU 14), Xuehai (SP 10), Zusanli (ST 36)
every other day; duration not mentionedresponse rate;
recurrence rate

Li and Yin 2015 [27]Parallel, 2 armsbloodletting, 27
cetirizine, 27
triangle-edged needle with cupping;
Yuji (LU 10), Dazhui (DU 14), Weizhong (BL 40), Chize (LU 5)
every other day; a total of 4 weeksresponse rate;
disease activity control;
recurrence rate;
adverse events

Li 2013 [28]Parallel, 2 armsbloodletting, 36
loratadine, 36
triangle-edged needle with cupping;
Xuehai (SP 10), Quchi (LI 11), Weizhong (BL 40)
every 3 days; 3 times for a course, a total of 2 coursesresponse rate;
adverse events

Wu et al. 2010 [29]Parallel, 2 armsbloodletting, 30
cetirizine, 30
plum-blossom needle with cupping;
Du meridian and Bladder Meridian
every other day; 10 times a course, a total of 2 courses, 5 days interval between coursesresponse rate

Zhao 2013 [30]
unpublished thesis
Parallel, 3 armsbloodletting, 30
mizolastine, 30
bloodletting plus mizolastine, 30
triangle-edged needle with cupping;
Dazhui (DU 14), Feishu (BL 13), Geshu (BL 17), Ganshu (BL 18), Pishu (BL 20)
every other day; 4 weeksresponse rate;
recurrence rate;
adverse events

Lv et al. 2006 [31]Parallel, 2 armsbloodletting plus cetirizine, 62
cetirizine, 48
triangle-edged needle with cupping;
Dazhui (DU 14), Feishu (BL 13), Dachangshu (BL 25), Pishu (BL 20), Shenshu (BL 23)
once a days for consecutive 4 days as a course; 3 days interval between courses; a total of 4 weeksresponse rate;
recurrence rate;
adverse events