An Angle Compared Index with Hybrid of Changes in the Ratio and Amplitude for Quantitative Evaluation of Disease Risk, Biological Function, and Biomarker Efficacy

Table 2

Combination of two different factors with the same Youden index, Odds ratio, and angle compared index (ACI) but different cardinal numbers.

Index	Marker	Group	One marker		Markers	Two markers (AA’ or BB’) combined
			Positive (%)	Index value		Positive (%)	Index value
Youden index	A	Disease	0.20	0.15	A and A’	0.36	0.26
		Control	0.05			0.10
	B	Disease	0.50	0.15	B and B’	0.75	0.17
		Control	0.35			0.58
Odds Ratio	A	Disease	0.20	4.75	A and A’	0.36	5.32
		Control	0.05			0.10
	B	Disease	0.72	4.78	B and B’	0.52	7.94
		Control	0.35			0.12
ACI	A	Disease	0.20	41.6	A and A’	0.36	49.1
		Control	0.05			0.10
	B	Disease	0.57	42.2	B and B’	0.82	49.3
		Control	0.30			0.51

A and A’ (or B and B’) are two different markers that are distributed at the same frequency in the two groups (disease group and control group) but are independent for each other.