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| Author | Type of the study | Number of infants | Interventions | Primary outcomes | Results |
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| Erickson-Owens, 2012 | Randomized controlled trial | 24 in term (>37 weeks of gestation) infants delivered by elective CS | UCM: 12
ICC: 12 | Hct levels at 36 to 48 h of age exposed to ICC or UCM | higher Hct levels at 36 to 48 h of age in UCM group |
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| Upadhyay, 2013 | Randomized controlled trial | 200 term and near-term infants (≥35 weeks of gestation) | C-UCM: 100
ICC: 100 | Hb and serum ferritin at 6 weeks of postnatal age | Mean Hb (11.9 [1.5] g/dL and mean serum ferritin 355.9 [182.6] μg/L) significantly higher in the C-UCM group Vs. ICC group (10.8 [0.9] g/dL and 177.5 [135.8] μg/L), respectively, at 6 weeks of age |
|
Jaiswal, 2015
PMID: 25800496 | Randomized controlled trial | 200 term infants (>36 weeks of gestation) | C-UCM: 100
DCC: 100 | Serum ferritin and Hb at 6 weeks of life | Mean serum ferritin (134.0 ng/ml [89.8]) and mean hemoglobin (11.0 gm/dl [2.4]) in C-UCM group was comparable to mean serum ferritin (142.7 ng/ml [87.1]) and hemoglobin (11.3 gm/dl [2.6]) in DCC group at 6 weeks of age |
|
Jaiswal, 2015
PMID: 26008758 | Randomized controlled trial | 200 term infants (>36 weeks of gestation) | C-UCM: 100
DCC: 100 | RI, PI and cerebral blood flow velocities of MCA at 24 to 48h of life | Mean PI [1.18 (0.26)] and RI [0.65 (0.08)] in UCM group was comparable to mean PI [1.18 (0.25)] and RI [0.65 (0.08)] in DCC group. The peak systolic velocity and end diastolic velocity (cm/s) of blood flow in MCA for UCM group were 34.94 (11.82) and 11.71 (4.75) respectively, while in DCC group they were 37.24 (12.63) and 13.07 (4.78) (p 0.23 and 0.07) respectively |
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| Bora, 2015 | Randomized controlled trial | Infants of non-anemic mothers (≥37 weeks of gestation): 90
Infants of anemic mothers: 89 | Infants of non-anemic mothers: ICC 45
C-UCM 45
Infants of anemic mothers: ICC 44
C-UCM 45 | Hb and serum ferritin concentrations at 6 months of age | Mean Hb concentration at 6 months was 9.60±1.42 g dl(-1) in the C-UCM group and 9.07±1.10 g dl(-1) in the ICC (P=0.004). Mean serum-ferritin concentration at 6 months was 113.9±43.8 ng ml(-1) in the C-UCM group and 70.8±39.5 ng/ml in the ICC (P<0.001) |
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| Yadav, 2015 | Randomized controlled trial | 300 neonates (≥37 weeks of gestation) | UCM: 100
DCC: 100
DCM: 100 | Hb and serum ferritin at 6 weeks of age | Median serum
ferritin at 6 weeks was significantly higher in the DCM group (295.49 (233.5 to 346.54) ng ml− 1) Vs. UCM group (184.55 (131.22 to 256.5)
ng ml− 1) or only DCC (268.8 (189.4 to 315.44) ng ml− 1). |
|
| Agarwal, 2016 | Follow-up study of a
randomized controlled trial | 161 (≥37 weeks of gestation) | UCM: 83
DCC: 78 | Hb and serum ferritin concentrations at 12 months of age | The mean Hb in the DCC group (102.2 (17.2) g/L and serum ferritin 16.44 (2.77) μg/L) showed no significant differences to the UCM group (98.6 (17.1) g/L and 18.2 (2.8) μg/L) at one year |
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| Katheria, 2018 | Retrospective analysis | 157 infants with abnormal cord gases (≥35 weeks of gestation) | UCM: 36
ICC: 121 | neonatal outcomes during hospitalization | Fewer infants in the UCM group needed resuscitation (38 vs. 56%, p = 0.07) and ongoing respiratory support (19 vs. 31%, p = 0.16) compared to the ICC |
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| McAdams, 2018 | Clinical comparative study | 60 women ≥37 weeks’ gestation | I-UCM:
15 3x Milkings
15 4x Milkings
C-UCM:
10 Cut10cm,
10 Cut20cm
10 Cut30cm | Placental transfusion blood volumes | Mean blood volume with I-UCM (×4) was increased compared to the 30 cm C-UCM technique (48.5 ± 19.0 vs. 24.8 ± 4.0 mL, P < 0.001). For C-UCM, blood volume increased proportionally to cord length and, by the second milking, 98.1 ± 4.5% of blood volume was delivered. |
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| Alzaree, 2018 | Randomized controlled trial | 250 (≥ 37 weeks’ gestation) | DCC: 125
UCM: 125 | Infant's Hb at 6 weeks after delivery | There was a significant statistical difference between cases delivered by UCM and those delivered by a DCC in Hb after 6 weeks |
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| Girish, 2018 | Quasi-randomized, non-blinded, controlled trial | 101 infants (≥35 weeks) who were depressed at birth | NO UCM:51
UCM: 50 | Feasibility and safety of UCM | No significant differences in resuscitation delay, resuscitation efforts, and short-term outcomes between the two groups. |
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