Computational Analysis of Protein Structure Changes as a Result of Nondeletion Insertion Mutations in Human β-Globin Gene Suggests Possible Cause of β-Thalassemia

Table 2

Root mean square deviation (RMSD) between the model structures of the sequences.

Model	Model 2	RMS	Sec. str.	Mutation
WILD	Seq1	1.115	Loop	Insertion
	Seq2	0.690	Loop	Insertion
	Seq3	1.115	Loop	Insertion
	Seq4	0.533	Loop	Insertion
	Seq5	0.534	Loop	Insertion
	Seq6	1.107	Loop	Insertion
Seq2	Seq1	0.246	Loop
	Seq3	0.246	Loop
	Seq4	0.247	Loop
	Seq5	0.256	Loop
	Seq6	0.135	Loop
Seq5	Seq4	0.013	Loop