The MicroRNA Family Both in Normal Development and in Different Diseases: The miR-17-92 Cluster

Table 1

The roles of the miR-17-92 cluster in different diseases.

Diseases	Function	References
Neurological Diseases	mediating adult neural progenitor cells proliferation and differentiation	[67]
	ameliorating neurogenesis and angiogenesis	[67]
	reducing anxiety- and depression-related behaviors	[68]
	remodeling the functional recovery of nerve	[37, 69]
Heart Disease	regulating cardiac proliferation	[36]
	leading to cardiomyocyte proliferation in embryonic, postnatal, and even adult hearts	[36]
	reversing cardiac dysfunction and cardiac fibrosis	[36]
	regulating the physiological and pathophysiological processes of atherosclerosis	[76]
	partaking the vulnerable carotid plaques activities such as inflammation, apoptosis, and angiogenesis	[76]
	preventing the occurrence of cardiomyopathy	[10]
Development of Bone	stimulating osteoblast proliferation, differentiation, and apoptosis	[84–86]
	accelerating bone metabolism	[12]
	reducing tissue volume and bone volume	[12, 86, 88]
	increasing alveolar bone width and decreasing of periodontal ligament space	[86]
	lessening the loss of trabecular bone	[86]
Tumors	causing tumorigenesis	[89]
	inhibiting tumor suppressor genes	[91]