Research Article
Influences of Corydalis decumbens on the Activities of CYP450 Enzymes in Rats with a Cocktail Approach
Table 2
Precision, accuracy, extraction recovery, and matrix effect of five probes in rat plasma (n=6).
| Analytes | Concentration added (ng/mL) | Intra-day | Inter-day | Recovery (%) | Matrix effect (%) | RSD (%) | RE (%) | RSD (%) | RE (%) |
| Phenacetin | 5 | 4.93 | 2.10 | 4.90 | -0.19 | 83.50 | 98.41 | 100 | 7.02 | 1.69 | 8.02 | 2.78 | 84.71 | 97.97 | 500 | 2.42 | -1.39 | 5.06 | -0.93 | 87.35 | 102.59 | Metoprolol | 5 | 10.85 | -0.88 | 9.74 | -0.39 | 88.98 | 95.26 | 100 | 8.27 | -3.41 | 9.16 | -2.74 | 90.76 | 97.67 | 500 | 4.70 | 1.86 | 5.90 | 0.42 | 87.24 | 97.27 | Midazolam | 2.5 | 8.01 | 4.40 | 8.82 | 0.68 | 85.62 | 95.46 | 25 | 8.60 | -0.48 | 9.22 | -2.21 | 84.02 | 96.47 | 100 | 5.65 | 0.77 | 7.56 | -0.28 | 87.48 | 97.82 | Omeprazole | 5 | 5.69 | -0.58 | 6.91 | 1.72 | 85.93 | 98.78 | 50 | 6.45 | 4.28 | 5.15 | -2.18 | 88.93 | 95.91 | 500 | 2.25 | 6.24 | 2.90 | 1.66 | 86.95 | 100.34 | Tolbutamide | 100 | 2.41 | -4.44 | 8.12 | 3.97 | 85.82 | 98.94 | 500 | 4.17 | 1.87 | 4.66 | -0.73 | 87.43 | 95.97 | 5000 | 3.28 | 0.41 | 4.23 | -1.19 | 86.85 | 99.18 |
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