Influences of Corydalis decumbens on the Activities of CYP450 Enzymes in Rats with a Cocktail Approach

Table 3

(a) Main pharmacokinetic parameters of six in rats (n=6, mean±SD)

Probe drugs	Parameters	Tz, h	CLz/F, L/h/kg	C, ng/ml	T,h
Phenacetin	Control	1.364±0.189	12.167±7.187	468.492±174.355	0.473±0.304
	XTW	2.005±0.084	6.489±3.258	715.237±216.924	0.528±0.266
Metoprolol	Control	2.175±0.350	3.256±1.240	595.115±176.562	3.000±0.894
	XTW	2.137±0.109	3.353±0.672	602.857±164.967	2.583±1.201
Midazolam	Control	5.426±0.323	31.808±13.079	57.127±22.704	0.723±0.429
	XTW	6.941±0.770	13.913±4.180	126.572±55.454	1.167±0.683
Omeprazole	Control	2.137±0.109	3.353±0.672	602.857±164.967	2.583±1.200
	XTW	1.435±0.222	160.865±125.736	53.273±28.328	0.335±0.181
Tolbutamide	Control	7.928±0.501	0.123±0.024	5753.637±1135.602	3.167±0.753
	XTW	8.196±0.400	0.122±0.016	5327.587±586.093	3.667±0.516

: significantly different from control, p<0.05. : significantly different from control, p<0.01.

(b) Main pharmacokinetic parameters of six in rats (n=6, mean±SD)

Probe drugs	Parameters	MRT,h	MRT,h	AUC, ng/ml·h	AUC, ng/ml·h
Phenacetin	Control	1.881±0.364	1.934±0.336	1158.538±790.101	1162.355±789.191
	XTW	2.460±0.294	2.630±0.336	1778.848±652.752	1802.074±657.140
Metoprolol	Control	4.191±0.387	4.629±0.449	3266.639±1033.756	3399.903±1078.993
	XTW	4.003±0.460	4.372±0.524	2995.480±681.621	3098.636±703.838
Midazolam	Control	6.114±0.409	7.178±0.583	354.710±170.609	371.116±182.508
	XTW	7.236±0.701	9.330±1.093	717.013±231.178	780.230±260.146
Omeprazole	Control	4.004±0.460	4.372±0.524	2995.480±681.621	3098.636±703.838
	XTW	1.747±0.160	1.941±0.176	88.440±45.975	90.921±47.286
Tolbutamide	Control	11.563±0.526	12.339±0.505	82485.815±16562.483	83822.392±16723.482
	XTW	11.897±0.709	12.742±0.850	81505.311±10227.159	82972.008±10446.975

: significantly different from control, p<0.05. : significantly different from control, p<0.01.