BioMed Research International / 2019 / Article / Tab 1

Review Article

Pharmacological Protection of Kidney Grafts from Cold Perfusion-Induced Injury

Table 1

Pharmacological strategies in the prevention of kidney ischemia-reperfusion.

StudySpeciesModelIschemia
(min)
ReperfusionInhibitorDoseEffect on
kidney function

[5]Knockout MMP-2−/− miceIn vivo6024hMinocycline45mg/kg↓ ATI
↓ Renal dysfunction
[5]Knockout MMP-2−/− miceIn vivo6024hMMP-2/MMP-9 Inhibitor III2.5mg/kg↓ ATI
↓ Renal dysfunction
[6]RatIn vivo10-Doxy100µM↓ LDH
↓ NGAL
↓ Cco
[6]RatIn vivo10-MMP-2 siRNA10µM
↓ LDH
↓ NGAL
↓ Cco
[7]RatIn vivo454wkSS-202mg/kg↓ Cytoskeletal breakdown
↓ Mitochondria matrix swelling
[8]RatIn vivo
606hTaurine200mg/kg↓ Degeneration tubular
architecture
↓ Inflammatory cell infiltration
↓ Renal dysfunction
[9]MiceIn Vivo45Up to 7 daysEverolimus0.25mg/kg↓ Kidney function
↓ Recovery of kidney function
[10]PigIn vivo2518h1400W10mg/kg↑ Renal function
↓ Oxidative stress
[11]MiceIn Vivo45Up to 24hMitoQ4mg/kg↓ Oxidative damage

SS-20: H-Phe-D-Arg-Phe-Lys-NH2; Taurine: 2-aminoethanesulfonic acid; Everolimus: RAD001; DOXY: doxycycline; wk: weeks; ↑: increased; ↓: decreased.

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