Pharmacological Protection of Kidney Grafts from Cold Perfusion-Induced Injury

Table 1

Pharmacological strategies in the prevention of kidney ischemia-reperfusion.


Study	Species	Model	Ischemia (min)	Reperfusion	Inhibitor	Dose	Effect on kidney function

[5]	Knockout MMP-2^−/− mice	In vivo	60	24h	Minocycline	45mg/kg	↓ ATI ↓ Renal dysfunction
[5]	Knockout MMP-2^−/− mice	In vivo	60	24h	MMP-2/MMP-9 Inhibitor III	2.5mg/kg	↓ ATI ↓ Renal dysfunction
[6]	Rat	In vivo	10	-	Doxy	100µM	↓ LDH ↓ NGAL ↓ Cco
[6]	Rat	In vivo	10	-	MMP-2 siRNA	10µM	↓ LDH ↓ NGAL ↓ Cco
[7]	Rat	In vivo	45	4wk	SS-20	2mg/kg	↓ Cytoskeletal breakdown ↓ Mitochondria matrix swelling
[8]	Rat	In vivo	60	6h	Taurine	200mg/kg	↓ Degeneration tubular architecture ↓ Inflammatory cell infiltration ↓ Renal dysfunction
[9]	Mice	In Vivo	45	Up to 7 days	Everolimus	0.25mg/kg	↓ Kidney function ↓ Recovery of kidney function
[10]	Pig	In vivo	25	18h	1400W	10mg/kg	↑ Renal function ↓ Oxidative stress
[11]	Mice	In Vivo	45	Up to 24h	MitoQ	4mg/kg	↓ Oxidative damage

SS-20: H-Phe-D-Arg-Phe-Lys-NH₂; Taurine: 2-aminoethanesulfonic acid; Everolimus: RAD001; DOXY: doxycycline; wk: weeks; ↑: increased; ↓: decreased.