Research Article

[Retracted] Fbxw7 and Skp2 Regulate Stem Cell Switch between Quiescence and Mitotic Division in Lung Adenocarcinoma

Figure 5

Fbxw7 inhibits tumor growth in lung adenocarcinoma xenograft models. (a) 3 × 105 A549 cells and 3 × 105 A549 cells with Fbxw7 stable expression were subcutaneously injected into nude mice and tumor formation was monitored. The nude mice were euthanized after 26 days and the photos of the nude mice and tumors are shown. (b) Growth course of the tumors. (c) Weights of the tumors harvested from mice at the end of experiments. (d) H&E staining of the tumors in the control and Fbxw7-overexpressing groups. All the results are expressed as mean ± SD (n = 3, p < 0.01).