TMT-Based Quantitative Proteomic Analysis Identification of Integrin Alpha 3 and Integrin Alpha 5 as Novel Biomarkers in Pathogenesis of Acute Aortic Dissection

Table 1

Upregulated differential abundance proteins in AAD patients ().

Accession	Expression of healthy donor	Mean expression of AAD patients ()	log2FC	Description
Q14315	324.67	7870.896	4.599	Filamin-C
Q5U0D2	204	3628.784	4.153	Transgelin
P37802	2044.82	28287.816	3.79	Transgelin-2
B0AZV6	471.5	5283.69	3.486	cDNA, FLJ79546, highly similar to SH3 domain-binding glutamic acid-rich-like protein
J3KND3	180	1960.68	3.445	Myosin light polypeptide 6
A8KAH9	565	6078.1	3.427	RAP1A, member of RAS oncogene family
A0A024QZQ2	267	2674.5	3.324	Prosaposin (Variant Gaucher disease and variant metachromatic leukodystrophy), isoform CRA_b
A0A024RAB6	368.77	3658.2	3.31	Heparan sulfate proteoglycan 2 (Perlecan), isoform CRA_b
P08294	718	6862.38	3.257	Extracellular superoxide dismutase [Cu-Zn]
F2RM37	315.5	2933.168	3.217	Coagulation factor IX
A0A024R321	236.44	2162.786	3.193	Filamin-B, beta (actin binding protein 278), isoform CRA_a
B4DHX4	241.5	2181.672	3.175	cDNA FLJ52902, highly similar to Rab GDP dissociation inhibitor alpha
A6NIZ1	565	5073.772	3.167	Ras-related protein Rap-1b-like protein
A0A024QZX3	180	1546.584	3.103	Serpin peptidase inhibitor, clade B (Ovalbumin), member 6, isoform CRA_a
Q53HQ0	270	2227.7	3.045	Flotillin 1 variant (fragment)
A6NLG9	252.8	2077.26	3.039	cDNA FLJ36740 fis, clone UTERU2013322, highly similar to Biglycan
A5YM53	229	1812.1875	2.984	ITGAV protein
V9HWF6	287.5	2256.258	2.972	Alpha 1-acid glycoprotein
B2RDY9	190	1426.9175	2.909	Adenylyl cyclase-associated protein
B4DLV7	311.17	2185.602	2.812	cDNA FLJ60299, highly similar to Rab GDP dissociation inhibitor beta
P01031	461	3067.166667	2.734	Complement C5
Q9NZM1	201	1334.328	2.731	Myoferlin
P13645	870.5	5446.79	2.645	Keratin, type I cytoskeletal 10
P08779	1462.67	8870.308	2.6	Keratin, type I cytoskeletal 16
B1N7B8	201	1028.0625	2.355	Cryocrystalglobulin CC1 kappa light chain variable region (fragment)
A0A024RBX9	256	1281.3	2.323	Pyruvate dehydrogenase E1 component subunit alpha
Q7Z7J6	241.25	1205.772	2.321	Actin alpha 1 skeletal muscle protein
B7Z6P1	266.05	1306.056	2.295	cDNA FLJ53662, highly similar to actin, alpha skeletal muscle
A8K4W0	347	1656.5	2.255	40S ribosomal protein S3a
A0A024R821	451	1989.75	2.141	Eukaryotic translation initiation factor 3 subunit B
P07357	947	4078	2.106	Complement component C8 alpha chain
G3V4G1	274	1140	2.057	Neuroguidin (fragment)

Note: based on protein abundance. A protein was defined as DAPs if there was a log2FC in excess of 2. FC: fold change.