Identification of Candidate Genes Associated with Charcot-Marie-Tooth Disease by Network and Pathway Analysis

Table 1

Pathways enriched in CMTgset.

Pathways	ID	value^a	BH value^b	Genes included in the pathway^c
Aminoacyl-tRNA biosynthesis	hsa00970			GARS1, WARS, AARS1, HARS1, MARS1, YARS1, KARS1
Metabolic pathways	hsa01100			NAGLU, GAMT, SGPL1, COX10, COX6A1, MTMR2, PRPS1, DNMT1, SPTLC2, HADHB, HK1, DGAT2, SPTLC1, POLG
Vasopressin-regulated water reabsorption	hsa04962			DCTN1, DCTN2, DYNC1H1
Sphingolipid metabolism	hsa00600			SGPL1, SPTLC2, SPTLC1
Amyotrophic lateral sclerosis (ALS)	hsa05014			SOD1, NEFL, NEFH
Salmonella infection	hsa05132			PFN2, RAB7A, DYNC1H1
Huntington’s disease	hsa05016			DCTN1, COX6A1, SOD1, DCTN2
Sphingolipid signaling pathway	hsa04071			SGPL1, SPTLC2, SPTLC1
Apoptosis	hsa04210			LMNA, TUBA8, AIFM1
Carbohydrate digestion and absorption	hsa04973			HK1, ATP1A1
Endocrine and other factor-regulated calcium reabsorption	hsa04961			ATP1A1, DNM2
Phagosome	hsa04145			TUBA8, RAB7A, DYNC1H1
Mineral absorption	hsa04978			ATP1A1, ATP7A
Central carbon metabolism in cancer	hsa05230			HK1, SCO2

CMTgset: Charcot-Marie-Tooth Disease-related gene set. ^a values were calculated by Fisher’s exact test. ^b values were adjusted by the Benjamini and Hochberg (BH) method. ^cOne hundred CMT-related genes included in the pathway.