BioMed Research International / 2020 / Article / Tab 1

Research Article

Identification of Candidate Genes Associated with Charcot-Marie-Tooth Disease by Network and Pathway Analysis

Table 1

Pathways enriched in CMTgset.

PathwaysID valueaBH valuebGenes included in the pathwayc

Aminoacyl-tRNA biosynthesishsa00970GARS1, WARS, AARS1, HARS1, MARS1, YARS1, KARS1
Metabolic pathwayshsa01100NAGLU, GAMT, SGPL1, COX10, COX6A1, MTMR2, PRPS1, DNMT1, SPTLC2, HADHB, HK1, DGAT2, SPTLC1, POLG
Vasopressin-regulated water reabsorptionhsa04962DCTN1, DCTN2, DYNC1H1
Sphingolipid metabolismhsa00600SGPL1, SPTLC2, SPTLC1
Amyotrophic lateral sclerosis (ALS)hsa05014SOD1, NEFL, NEFH
Salmonella infectionhsa05132PFN2, RAB7A, DYNC1H1
Huntington’s diseasehsa05016DCTN1, COX6A1, SOD1, DCTN2
Sphingolipid signaling pathwayhsa04071SGPL1, SPTLC2, SPTLC1
Apoptosishsa04210LMNA, TUBA8, AIFM1
Carbohydrate digestion and absorptionhsa04973HK1, ATP1A1
Endocrine and other factor-regulated calcium reabsorptionhsa04961ATP1A1, DNM2
Phagosomehsa04145TUBA8, RAB7A, DYNC1H1
Mineral absorptionhsa04978ATP1A1, ATP7A
Central carbon metabolism in cancerhsa05230HK1, SCO2

CMTgset: Charcot-Marie-Tooth Disease-related gene set. a values were calculated by Fisher’s exact test. b values were adjusted by the Benjamini and Hochberg (BH) method. cOne hundred CMT-related genes included in the pathway.

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