Identification of Candidate Genes Associated with Charcot-Marie-Tooth Disease by Network and Pathway Analysis

Table 2

Genes included in CMT top three specific PPI networks but not in the CMTgset.

Gene symbol	Gene name	Cluster
MTMR1	Myotubularin-related protein 1	Clusters A, B, and C
AATK	Apoptosis-associated tyrosine kinase	Clusters A, B, and C
HSF1	Heat shock transcription factor 1	Clusters A, B, and C
PNISR	PNN interacting serine and arginine-rich protein	Clusters A, B, and C
HSPB6	Heat shock protein family B (small) member 6	Clusters A, B, and C
CRYAB	Crystallin alpha B	Clusters A, B, and C
HSPA4	Heat shock protein family A (Hsp70) member 4	Clusters A, B, and C
STUB1	STIP1 homology and U-box containing protein 1	Clusters A, B, and C
MLF2	Myeloid leukemia factor 2	Clusters A, B, and C
HSP90AB1	Heat shock protein 90 alpha family class B member 1	Clusters A, B, and C
SQSTM1	Sequestosome 1	Clusters A, B, and C
MAGED1	MAGE family member D1	Clusters A, B, and C
IRAK1	Interleukin 1 receptor-associated kinase 1	Clusters A, B, and C
EGFR	Epidermal growth factor receptor	Clusters A, B, and C
SNW1	SNW domain containing 1	Clusters A, B, and C
CDC5L	Cell division cycle 5 like	Clusters A, B, and C
PKN1	Protein kinase N1	Clusters A, B, and C
DYNLT1	Dynein light chain Tctex-type 1	Clusters A and B
GRB2	Growth factor receptor bound protein 2	Clusters A and B
NINL	Ninein like	Clusters A and B
DCTN5	Dynactin subunit 5	Clusters A and B
BICD2	BICD cargo adaptor 2	Clusters A and B
SCLT1	Sodium channel and clathrin linker 1	Clusters A and B
ACTR1A	Actin-related protein 1A	Clusters A and B
MAPRE1	Microtubule-associated protein RP/EB family member 1	Clusters A and B
NIN	Ninein	Clusters A and B
DCTN4	Dynactin subunit 4	Clusters A and B
HSP90AA1	Heat shock protein 90 alpha family class A member 1	Clusters A and B
CNTRL	Centriolin	Cluster B
TMEM17	Transmembrane protein 17	Cluster B

CMT = Charcot-Marie-Tooth Disease; PPI = protein-protein interaction.