Associations between NLRC4 Gene Polymorphisms and Autoimmune Thyroid Disease

Table 4

Odds ratios (ORs) of the associations of four polymorphisms in the NLRC4 gene with GD before and after adjusting for confounders (age and gender).

Comparison models	Unadjusted estimates		Adjusted estimates
	OR (95% CI)	values	OR (95% CI)	values
rs385076
Allele model	0.86 (0.74-1.01)	0.063	0.86 (0.73-1.01)	0.061
Dominant model	0.85 (0.68-1.06)	0.141	0.84 (0.68-1.05)	0.130
Recessive model	0.87 (0.58-1.06)	0.117	0.79 (0.58-1.07)	0.125
Homozygous model	0.85 (0.72-1.01)	0.064	0.85 (0.72-1.01)	0.063
rs455060
Allele model	0.91 (0.78-1.06)	0.215	0.91 (0.78-1.06)	0.235
Dominant model	0.93 (0.74-1.18)	0.559	0.94 (0.75-1.18)	0.598
Recessive model	0.81 (0.62-1.07)	0.134	0.82 (0.62-1.07)	0.142
Homozygous model	0.90 (0.77-1.05)	0.173	0.90 (0.77-1.05)	0.185
rs212704
Allele model	0.90 (0.77-1.05)	0.169	0.91 (0.78-1.05)	0.203
Dominant model	0.92 (0.73-1.16)	0.469	0.93 (0.74-1.17)	0.525
Recessive model	0.81 (0.62-1.05)	0.115	0.81 (0.62-1.07)	0.134
Homozygous model	0.89 (0.76-1.04)	0.138	0.89 (0.77-1.04)	0.158
rs675712
Allele model	1.02 (0.88-1.18)	0.791	1.03 (0.89-1.19)	0.704
Dominant model	0.96 (0.77-1.20)	0.723	0.98 (0.79-1.22)	0.864
Recessive model	1.14 (0.87-1.49)	0.351	1.14 (0.86-1.50)	0.360
Homozygous model	1.04 (0.90-1.21)	0.601	1.05 (0.90-1.22)	0.540

GD: Graves’ disease; OR: odds ratio; 95% CI: 95% confidence interval; age and gender were adjusted in the multivariate logistic regression analyses.