Research Article
Associations between NLRC4 Gene Polymorphisms and Autoimmune Thyroid Disease
Table 8
Allele frequencies and genotype distribution of NLRC4 polymorphisms with hypothyroidism in HT patients.
| | SNPs | Without (%) | With (%) | value | OR (95% CI) |
| | rs385076 | | | T | 278 (62.90) | 205 (66.13) | 0.363 | 0.87 (0.64-1.18) | | C | 164 (37.10) | 105 (33.87) | | TT | 89 (40.27) | 67 (43.22) | 0.589 | — | | TC | 100 (45.25) | 71 (45.81) | | CC | 32 (14.48) | 17 (10.97) | | rs455060 | | | A | 187 (42.31) | 138 (44.52) | 0.547 | 0.91 (0.68-1.23) | | G | 255 (57.69) | 172 (55.48) | | AA | 41 (18.55) | 31 (20.00) | 0.823 | — | | AG | 105 (47.51) | 76 (49.03) | | GG | 75 (33.94) | 48 (30.97) | | rs212704 | | | T | 185 (41.86) | 140 (45.16) | 0.368 | 0.874 (0.65-1.17) | | C | 257 (58.14) | 170 (54.84) | | TT | 39 (17.65) | 30 (19.35) | 0.601 | — | | TC | 107 (48.42) | 80 (51.61) | | CC | 75 (33.94) | 45 (29.03) | | rs675712 | | | A | 266 (60.18) | 181 (58.39) | 0.622 | 1.08 (0.80-1.45) | | G | 176 (39.82) | 129 (41.61) | | AA | 81 (36.65) | 52 (33.55) | 0.823 | — | | AG | 104 (47.06) | 77 (49.68) | | GG | 36 (16.29) | 26 (16.77) |
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HT: Hashimoto’s thyroiditis; OR: odds ratio; 95% CI: 95% confidence interval.
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