Autophagy Inhibition Potentiates the Anticancer Effects of a Bendamustine Derivative NL-101 in Acute T Lymphocytic Leukemia

Figure 1

NL-101 inhibits proliferation of T-ALL in a dose- and time-dependent manner. T-ALL cells were seeded into 96-well plates with fresh RPMI-1640 medium with NL-101 (a), vorinostat, and bendamustine (b) at indicated concentrations. Cell viability was assessed by MTT analysis and IC₅₀ values were calculated. Data are representative of three independent experiments. (c) The structure of NL-101.

(a)

(b)

(c)