Research Article
Effects of Dexmedetomidine on the Pharmacokinetics of Parecoxib and Its Metabolite Valdecoxib in Beagles by UPLC-MS/MS
Table 3
The stability of two analytes in beagle plasma (
, ).
| | Compounds | Added (ng/mL) | Room temperature, 12 h | Autosampler 4°C, 12 h | Three freeze-thaw | -20°C, 4 weeks | | RSD (%) | RE (%) | RSD (%) | RE (%) | RSD (%) | RE (%) | RSD (%) | RE (%) |
| | Parecoxib | 10 | 5.32 | -2.55 | 4.35 | 0.67 | 6.97 | 3.58 | 4.68 | 3.43 | | 500 | 3.08 | -1.20 | 4.79 | -0.80 | 4.83 | -1.31 | 4.62 | 2.72 | | 3000 | 1.60 | 1.23 | 1.72 | 1.75 | 3.54 | 0.55 | 2.53 | -2.08 | | Valdecoxib | 10 | 4.34 | 2.63 | 4.59 | 1.38 | 4.37 | 3.18 | 2.39 | -5.15 | | 500 | 5.17 | 1.56 | 5.71 | -1.31 | 6.87 | 3.03 | 5.29 | 1.13 | | 3000 | 2.19 | -1.19 | 2.25 | 0.98 | 2.14 | -1.36 | 1.44 | 2.49 |
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