Association of EPAS1 and PPARA Gene Polymorphisms with High-Altitude Headache in Chinese Han Population

Table 2

SNP information and genotype distribution in 580 subjects.


SNP	Allele	Gene	Chromosome position	N	Genotype frequencies	MAF (%)	value for HWE test

rs13419896	G/A	EPAS1	Chr2:46329206	577	0.47/0.43/0.10	31.0	1.000
rs4953354	A/G	EPAS1	Chr2:46348249	580	0.76/0.23/0.01	13.0	0.460
rs6756667	G/A	EPAS1	Chr2:46352270	580	0.78/0.21/0.01	11.0	0.680
rs7292407	C/A	PPARA	Chr22:46057832	549	0.74/0.23/0.03	15.0	0.090
rs6520015	T/C	PPARA	Chr22:46067551	580	0.69/0.28/0.03	17.0	0.770
rs4253623	A/G	PPARA	Chr22:46154203	575	0.75/0.23/0.02	13.0	1.000
rs135538	G/C	PPARA	Chr22:46168728	577	0.33/0.46/0.21	44.0	0.180
rs4253681	T/C	PPARA	Chr22:46183703	579	0.64/0.32/0.04	20.0	0.890
rs4253747	T/A	PPARA	Chr22:46217340	580	0.63/0.33/0.04	27.0	0.900
rs2009873	A/G	EGLN1	Chr1:231363490	576	0.34/0.48/0.18	42.0	0.550
rs2066140	G/C	EGLN1	Chr1:231368565	578	0.34/0.48/0.18	42.0	0.800
rs2739513	A/G	EGLN1	Chr1:231379455	563	0.34/0.48/0.18	42.0	0.600
rs2486736	A/G	EGLN1	Chr1:231385732	572	0.33/0.49/0.18	42.0	1.000
rs480902	C/T	EGLN1	Chr1:231395881	579	0.34/0.48/0.18	42.0	0.860
rs508618	A/G	EGLN1	Chr1:231396566	578	0.78/0.21/0.01	11.0	0.130
rs2790882	A/G	EGLN1	Chr1:231397037	575	0.33/0.49/0.18	43.0	0.930
rs2486729	A/G	EGLN1	Chr1:231399838	576	0.34/0.45/0.20	43.0	0.089
rs7542797	A/C	EGLN1	Chr1:231418041	577	0.76/0.22/0.01	12.0	0.850
rs1339891	G/A	EGLN1	Chr1:231420649	579	0.81/0.18/0.01	10.0	1.000
rs12406290	A/G	EGLN1	Chr1:231423480	561	0.28/0.49/0.22	47.0	0.870
rs2153364	A/G	EGLN1	Chr1:231424474	530	0.28/0.49/0.23	48.0	0.073
rs2275279	A/T	EGLN1	Chr1:231591348	579	0.54/0.38/0.08	27.0	0.250
rs2301104	G/C	HIF1A	Chr14:61698310	579	0.87/0.13/0.00	7.0	0.500
rs12434438	A/G	HIF1A	Chr14:61730580	568	0.56/0.39/0.05	24.0	0.170
rs966824	C/T	HIF1A	Chr14:61733800	574	0.68/0.30/0.02	17.0	0.380
rs2301112	A/C	HIF1A	Chr14:61739455	545	0.91/0.09/0.00	5.0	1.000
rs2301113	A/C	HIF1A	Chr14:61739830	576	0.43/0.46/0.10	34.0	0.400
rs2295778	C/G	HIF1AN	Chr10:100536079	578	0.58/0.36/0.06	24.0	0.910
rs11190602	T/C	HIF1AN	Chr10:100537499	578	0.78/0.20/0.02	12.0	0.420
rs3750633	G/A	HIF1AN	Chr10:100548457	579	0.85/0.14/0.01	8.0	0.390
rs10883512	A/G	HIF1AN	Chr10:100548759	579	0.85/0.14/0.01	8.0	0.560
rs11816840	G/C	HIF1AN	Chr10:100549463	579	0.85/0.14/0.01	8.0	0.770
rs1054399	C/T	HIF1AN	Chr10:100552808	579	0.85/0.14/0.01	8.0	0.390
rs11292	T/C	HIF1AN	Chr10:100553850	580	0.85/0.14/0.01	8.0	0.390
rs11190613	T/C	HIF1AN	Chr10:100554240	580	0.85/0.14/0.01	8.0	0.390

SNP, single nucleotide polymorphism; MAF, minor allele frequency; HWE, Hardy–Weinberg equilibrium.

BioMed Research International

Association of EPAS1 and PPARA Gene Polymorphisms with High-Altitude Headache in Chinese Han Population

Table 2