Association of EPAS1 and PPARA Gene Polymorphisms with High-Altitude Headache in Chinese Han Population
Table 4
Association between SNPs in PPARA and HAH under multiple genetic models.
SNP
Model
Allele/genotype
HAH+ [n (%)]
HAH− [n (%)]
OR (95% CI)
value
OR (95% CI)a
valuea
rs7292407
Allele
C
685 (86.5)
251 (82.0)
0.061
A
107 (13.5)
55 (18.0)
Codominant
CC
301 (76.0)
103 (67.3)
1
0.110
1
0.150
CA
83 (21.0)
45 (29.4)
0.63 (0.41–0.97)
0.64 (0.42–1.00)
AA
12 (3.0)
5 (3.3)
0.82 (0.28–2.39)
0.93 (0.31–2.79)
Dominant
CC
301 (76.0)
103 (67.3)
1
0.041
1
0.066
CA/AA
95 (24.0)
50 (32.7)
0.65 (0.43–0.98)
0.67 (0.44–1.02)
Recessive
CC/CA
384 (97.0)
148 (96.7)
1
0.890
1
0.930
AA
12 (3.0)
5 (3.3)
0.93 (0.32–2.67)
1.05 (0.35–3.11)
rs6520015
Allele
T
711 (84.4)
249 (78.3)
0.014
C
131 (15.6)
69 (21.7)
Codominant
TT
302 (71.7)
96 (60.4)
1
0.034
1
0.059
CT
107 (25.4)
57 (35.9)
0.60 (0.40–0.89)
0.61 (0.41–0.92)
CC
12 (2.8)
6 (3.8)
0.64 (0.23–1.74)
0.72 (0.25–2.02)
Dominant
TT
302 (71.7)
96 (60.4)
1
0.009
1
0.018
CT/CC
119 (28.3)
63 (39.6)
0.60 (0.41–0.88)
0.62 (0.42–0.92)
Recessive
TT/CT
409 (97.2)
153 (96.2)
1
0.570
1
0.750
CC
12 (2.8)
6 (3.8)
0.75 (0.28–2.03)
0.84 (0.30–2.35)
Allelic frequencies were compared by Chi-squared test (2 2 contingency table, df = 1). Association between SNPs and HAH under different models was detected by using binary logistic regression. aAdjusted for age, height, weight, BMI, smoking and drinking status, HR, SpO2, SBP, and DBP. indicated statistical significance. HAH+, subjects with HAH; HAH−, subjects without HAH. See Table 3 for group abbreviations.
