BioMed Research International

Research Article

Association of EPAS1 and PPARA Gene Polymorphisms with High-Altitude Headache in Chinese Han Population

Table 6

Distributions of PPARA haplotypes and the association with HAH risk.


Haplotypes		Frequencies		OR (95% CI)	value	OR (95% CI)^a	value^a
Haplotypes		HAH+	HAH−	OR (95% CI)	value	OR (95% CI)^a	value^a

rs7292407	rs6520015
C	T	0.783	0.826	1		1
A	C	0.175	0.147	0.71 (0.50–1.01)	0.057	0.74 (0.52–1.06)	0.110
C	C	0.042	0.026	0.41 (0.19–0.89)	0.024	0.41 (0.19–0.92)	0.030
Global haplotype association value: 0.045

rs4253623	rs135538
A	G	0.552	0.565	1		1
A	C	0.316	0.293	1.09 (0.83–1.45)	0.530	1.14 (0.86–1.53)	0.370
G	C	0.131	0.137	0.97 (0.66–1.45)	0.900	1.02 (0.68–1.53)	0.940
Global haplotype association value: 0.710

Associations between PPARA haplotypes and HAH risk were detected by binary logistic regression. ^aAdjusted for age, height, weight, BMI, smoking and drinking status, HR, SpO₂, SBP, and DBP. indicated statistical significance. HAH+, subjects with HAH; HAH−, subjects without HAH. See Table 3 for group abbreviations.