BioMed Research International / 2020 / Article / Tab 6

Research Article

Association of EPAS1 and PPARA Gene Polymorphisms with High-Altitude Headache in Chinese Han Population

Table 6

Distributions of PPARA haplotypes and the association with HAH risk.

HaplotypesFrequenciesOR (95% CI) valueOR (95% CI)a valuea
HAH+HAH−

rs7292407rs6520015
CT0.7830.82611
AC0.1750.1470.71 (0.50–1.01)0.0570.74 (0.52–1.06)0.110
CC0.0420.0260.41 (0.19–0.89)0.0240.41 (0.19–0.92)0.030
Global haplotype association value: 0.045

rs4253623rs135538
AG0.5520.56511
AC0.3160.2931.09 (0.83–1.45)0.5301.14 (0.86–1.53)0.370
GC0.1310.1370.97 (0.66–1.45)0.9001.02 (0.68–1.53)0.940
Global haplotype association value: 0.710

Associations between PPARA haplotypes and HAH risk were detected by binary logistic regression. aAdjusted for age, height, weight, BMI, smoking and drinking status, HR, SpO2, SBP, and DBP. indicated statistical significance. HAH+, subjects with HAH; HAH−, subjects without HAH. See Table 3 for group abbreviations.