BioMed Research International / 2020 / Article / Fig 2

Research Article

CDKL2 Is Associated with HER2 Status and Overall Survival in Gastric Cancer: Comparative Analysis of CDKL2 Protein Expression and Gene Copy Number

Figure 2

CDKL2 gene copy number detected by FISH. (a–c) Representative images of different CDKL2 gene copy number variants by FISH. (a) Negative FISH result: average CDKL2 copy number was 2.0, the ratio of CDKL2 to chromosome was 1.0. (b) Negative FISH result: average CDKL2 copy number was 3.3, the ratio of CDKL2 to chromosome was 1.4. (c) Positive FISH result: average CDKL2 copy number was 7.3, the ratio of CDKL2 to chromosome was 2.4. (d) The patient number in different levels of CDKL2 gene copy number. (e) The ratio of patients with positive HER2 status was significantly higher in the CDKL2 FISH+ group than in the CDKL2 FISH- group (). FISH: fluorescent in situ hybridization; CNV: copy number variation; CEP: centromeric probe.
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