CDKL2 Is Associated with HER2 Status and Overall Survival in Gastric Cancer: Comparative Analysis of CDKL2 Protein Expression and Gene Copy Number
Table 1
Patient characteristics according to the CDKL2 expression by IHC and FISH.
All patients
CDKL2-IHC low
CDKL2-IHC high
CDKL2-FISH low
CDKL2-FISH high
Variable
No.
%
No.
%
No.
%
No.
%
No.
%
Gender
Male
228
68.3
149
65.4
79
34.6
0.770
203
89.0
25
11.0
0.087
Female
106
31.7
71
67.0
35
33.0
93
87.7
13
12.3
Age
>60
155
46.4
101
65.2
54
34.8
0.800
135
87.1
20
12.9
0.414
≤60
179
53.6
119
66.5
60
33.5
161
89.9
18
10.1
Histologic grade
Moderate
51
15.3
34
66.7
17
33.3
0.896
44
86.3
7
13.7
0.566
Poor
283
84.7
186
65.7
97
34.3
252
89.0
31
11.0
TNMa
1-2
141
42.2
99
70.2
42
29.8
0.152
124
87.9
17
12.1
0.738
3-4
193
57.8
121
62.7
72
37.3
172
89.1
21
10.9
Lauren classification
Intestinal
102
30.5
67
65.7
35
34.3
0.805
86
84.3
16
15.7
0.158
Diffuse
167
50.0
108
64.7
59
35.3
149
89.2
18
10.8
Mixed
65
19.5
45
69.2
20
30.8
61
93.8
4
6.2
T
1-2
83
24.9
54
65.1
29
34.9
0.858
74
89.2
9
10.8
0.860
3-4
251
75.1
166
66.1
85
33.9
222
88.4
29
11.6
N
N0
97
29.0
63
64.9
34
35.1
0.821
89
91.8
8
8.2
0.249
N1-3
237
71.0
157
66.2
80
33.8
207
87.3
30
12.7
M
M-
292
86.8
198
67.9
94
32.1
0.049
259
88.7
33
11.3
0.908
M+
42
13.2
22
52.4
20
47.6
37
88.1
5
11.9
LVI
+
122
36.5
76
62.3
46
37.7
0.296
109
89.3
13
10.7
0.753
-
212
63.5
144
67.9
68
32.1
187
88.2
25
11.8
PNI
+
194
58.1
121
62.4
73
37.6
0.113
169
87.1
25
12.9
0.306
-
140
41.9
99
70.7
41
29.3
127
90.7
13
9.3
Tumor location
Cardia
54
16.2
36
66.7
18
33.3
0.892
50
94.4
4
5.6
0.316
Other
280
83.8
184
65.7
96
34.3
246
87.9
34
12.1
HER2 status
+
45
13.5
20
44.4
25
55.6
0.001
33
73.3
12
26.7
0.001
-
289
86.5
200
69.2
89
30.8
263
91.0
26
9.0
aClinical stage were reclassified according to the 8th American Joint Committee on Cancer (AJCC) TNM classification. LVI: lymph-vascular invasion; PNI: perineural invasion.
