CDKL2 Is Associated with HER2 Status and Overall Survival in Gastric Cancer: Comparative Analysis of CDKL2 Protein Expression and Gene Copy Number

Table 2

Cox proportional hazard model analysis of prognostic factors.

Variables	Univariate analysis			Multivariate analysis
	HR	95% CI		HR	95% CI
CDKL2 H-score (high vs. low)	1.848	1.325-2.576	<0.001	1.322	0.894-1.954	0.162
CDKL2 gene copy number (high vs. low)	1.801	1.151-2.818	0.010	1.160	0.694-1.938	0.571
Sex (male vs. female)	1.023	0.720-1.388	0.1453	—	—	—
Age (≥60 vs. <60 years)	1.809	1.299-2.518	<0.001	1.695	1.172-2.452	0.005
Depth of invasion (T3/T4 vs. T1/T2)	3.518	2.090-5.922	<0.001	2.024	1.021-4.012	0.043
Lymph node metastasis (N3 vs. other)	2.717	1.954-3.779	<0.001	1.270	0.831-1.940	0.270
Distant metastasis; (M1 vs. other)	3.154	2.113-4.709	<0.001	1.742	1.104-2.748	0.017
TNM stage (III + IV vs. I + II)	3.035	2.077-4.433	<0.001	4.350	2.297-8.238	<0.001
Differentiation (poor vs. moderate)	1.045	0.663-1.645	0.851	—	—	—
Lauren classification (intestinal vs. diffuse vs. mixed)	1.014	0.709-1.450	0.940	—	—	—
Lymph-vascular invasion (positive vs. negative)	2.519	1.812-3.501	<0.001	1.543	1.047-2.275	0.028
Perineural invasion (positive vs. negative)	2.593	1.788-3.762	<0.001	1.555	0.992-2.436	0.054
HER2 status (positive vs. negative)	3.040	2.051-4.505	<0.001	2.449	1.611-3.722	<0.001
Location (cardia vs. other)	1.402	0.921-2.132	0.115	—	—	—

IHC: immunohistochemical; HR: hazard ratio; CI: confidence interval; was considered statistically significant.