BioMed Research International / 2020 / Article / Tab 2

Research Article

CDKL2 Is Associated with HER2 Status and Overall Survival in Gastric Cancer: Comparative Analysis of CDKL2 Protein Expression and Gene Copy Number

Table 2

Cox proportional hazard model analysis of prognostic factors.

VariablesUnivariate analysisMultivariate analysis
HR95% CIHR95% CI

CDKL2 H-score (high vs. low)1.8481.325-2.576<0.0011.3220.894-1.9540.162
CDKL2 gene copy number (high vs. low)1.8011.151-2.8180.0101.1600.694-1.9380.571
Sex (male vs. female)1.0230.720-1.3880.1453
Age (≥60 vs. <60 years)1.8091.299-2.518<0.0011.6951.172-2.4520.005
Depth of invasion (T3/T4 vs. T1/T2)3.5182.090-5.922<0.0012.0241.021-4.0120.043
Lymph node metastasis (N3 vs. other)2.7171.954-3.779<0.0011.2700.831-1.9400.270
Distant metastasis
(M1 vs. other)
3.1542.113-4.709<0.0011.7421.104-2.7480.017
TNM stage (III + IV vs. I + II)3.0352.077-4.433<0.0014.3502.297-8.238<0.001
Differentiation (poor vs. moderate)1.0450.663-1.6450.851
Lauren classification (intestinal vs. diffuse vs. mixed)1.0140.709-1.4500.940
Lymph-vascular invasion (positive vs. negative)2.5191.812-3.501<0.0011.5431.047-2.2750.028
Perineural invasion (positive vs. negative)2.5931.788-3.762<0.0011.5550.992-2.4360.054
HER2 status (positive vs. negative)3.0402.051-4.505<0.0012.4491.611-3.722<0.001
Location (cardia vs. other)1.4020.921-2.1320.115

IHC: immunohistochemical; HR: hazard ratio; CI: confidence interval; was considered statistically significant.

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