Effects of 2,3,7,8-Tetrachlorodibenzo-p-dioxin on T Cell Differentiation in Primary Biliary Cholangitis

Figure 5

TCDD-treated DCs affect naïve T cell differentiation. TCDD-treated DCs were cocultured with naïve CD4⁺ T cells, and the cell ratios of Th1, Th2, and Th17 were detected by FACS. In the PBC group, the differences of cell ratio (%) of IFN-γ (a), IL-4 (b), IL-17 (c), and Foxp3 (d) were analysis in the different groups by statistical analysis (e). The cells ratio of Th1 and Th17 of the PBC DC+PBC T cell group was higher than the HC DC+HC T cell group. The cells ratio of Th2 showed no significant differences between the HC and PBC groups. Data are expressed as (, , and ).