ChoK-ing the Pathogenic Bacteria: Potential of Human Choline Kinase Inhibitors as Antimicrobial Agents

Figure 4

Amino acid sequence alignment of ChoK C-terminal from human and selected pathogenic bacteria. Sequence alignment was made by Clustal Omega available at https://www.ebi.ac.uk/Tools/msa/clustalo/ [111]. Asterisk, colon, and period indicate single fully conserved residue, conservation between groups of strongly similar properties, and conservation between groups of weakly similar properties, respectively. Inverted blue triangles indicate the hydrophobic residues forming interactions with HC-3 in hChoK alpha [110]. The blue circle indicates the hydrophobic residue that influences the plasticity of HC-3 binding groove. GenBank accession numbers for Human-CKalpha (NP001268.2), K. pneumoniae (PUG97579.1), P. aeruginosa (PTZ28970.1), B. cenocepacia (ODN63053.1), T. pallidum (APT97059.1), H. influenzae (AIB45944.1), N. meningitidis (SPY01484.1), C. botulinum (KON14313.1), S. pneumoniae (VTW72173.1), Bacillus sp. (AFS006103), M. tuberculosis (SGD50227.1), V. cholerae (QEO43700.1), and S. aureus (AXU08810.1) are shown.