Relation of Fibrinogen-to-Albumin Ratio to Severity of Coronary Artery Disease and Long-Term Prognosis in Patients with Non-ST Elevation Acute Coronary Syndrome
Table 1
Baseline and clinical characteristics.
Variable
Group 1 ()
Group 2 ()
Group 3 ()
value
FAR, %
7.8 (6.8, 8.2)
9.5 (9.1, 9.9)
11.7 (11.0, 12.8)
<0.001
Age, years
<0.001
Female
117 (30.9%)
161 (42.4%)
151 (39.8%)
0.003
BMI, kg/m2
0.606
SBP, mmHg
0.881
DBP, mmHg
0.401
Hypertension
267 (70.4%)
280 (73.7%)
281 (74.1%)
0.461
Diabetes mellitus
102 (26.9%)
127 (33.4%)
136 (35.9%)
0.024
Smoker
106 (28.0%)
105 (27.6%)
94 (24.8%)
0.557
Family history of CAD
11 (2.9%)
7 (1.8%)
5 (1.3%)
0.288
History of cerebrovascular disease
88 (23.2%)
80 (21.1%)
91 (24.0%)
0.603
Atrial fibrillation
28 (7.4%)
27 (7.1%)
33 (8.7%)
0.678
Biochemical indicators
Leukocyte count, 109/L
6.2 (5.3, 7.4)
6.5 (5.5, 7.8)
7.0 (5.8, 8.6)
<0.001
Hemoglobin, g/L
142 (132, 152)
137 (127, 147)
132 (120, 143)
<0.001
Platelet count, 109/L
196 (161, 233)
195 (163, 235)
208 (170, 256)
0.001
PT, s
0.152
APTT, s
0.446
D-dimer, μg/L
76 (43, 131)
103 (61, 169)
145 (88, 256)
<0.001
TnI, ng/mL
0 (0,0.01)
0 (0,0.02)
0.01 (0,0.10)
<0.001
CK, U/L
87.0 (65.3,128.0)
83.0 (56.3,122.8)
87.0 (56.3,136.0)
0.084
CK-MB, ng/mL
8.8 (3.4,12.9)
8.9 (4.2,13.5)
8.2 (3.2,13.8)
0.597
Glucose, mmol/L
5.8 (5.2, 7.0)
5.9 (5.3, 7.4)
6.0 (5.2, 8.2)
0.034
Creatinine, μmol/L
75 (64, 87)
76 (66, 89)
80 (68, 97)
<0.001
Uric acid, μmol/L
353 (296, 412)
343 (285, 420)
374 (299, 438)
0.003
Triglycerides, mmol/L
1.5 (1.0, 2.2)
1.4 (1.0, 2.0)
1.4 (1.0, 2.0)
0.186
Total cholesterol, mmol/L
0.759
LDL-C, mmol/L
0.516
Echocardiography
LVEF, %
67 (63, 72)
67.4 (62.0, 72.0)
65.2 (58.0, 72.0)
0.032
Clinical presentation
<0.001
Unstable angina
319 (84.2%)
314 (82.6%)
253 (66.8%)
NSTEMI
60 (15.8%)
66 (17.4%)
126 (33.2%)
Coronary angiography
Number of stents
0.753
Left main disease
23 (6.1%)
29 (7.6%)
36 (9.5%)
0.209
Three-vessel disease
130 (34.3%)
154 (40.5%)
188 (49.6%)
<0.001
Long lesion
181 (47.8%)
198 (52.1%)
215 (56.7%)
0.047
Calcified lesion
55 (14.5%)
80 (21.1%)
92 (24.3%)
0.003
Gensini Score
48 (31, 75)
52 (32, 87)
63 (42, 96)
<0.001
Medication use at discharge
Aspirin
370 (97.6%)
372 (97.9%)
375 (98.9%)
0.362
Clopidogrel/ticagrelor
378 (99.7%)
380 (100%)
378 (99.7%)
0.555
ACEI/ARB
192 (50.7%)
216 (56.8%)
222 (58.6%)
0.070
Beta blockers
284 (74.9%)
295 (77.6%)
311 (82.1%)
0.056
Statin
377 (99.5%)
379 (99.7%)
379 (100%)
0.554
BMI: body mass index; SBP: systolic blood pressure; DBP: diastolic blood pressure; CAD: coronary artery disease; PT: prothrombin time; APTT: activated partial thromboplastin time; TnI: troponin I; CK: creatine kinase; CK-MB: creatine kinase-MB; LDL-C: low-density lipoprotein cholesterol; FAR: fibrinogen-to-albumin ratio; LVEF: left ventricular ejection fraction; NSTEMI: non-ST elevation myocardial infarction; ACEI: angiotensin-converting enzyme inhibitor; ARB: angiotensin receptor blocker. Data are presented as the , median (25th-75th interquartile range), or (%).
