Influence of Different Dosage Forms on Pharmacokinetics of 6 Alkaloids in Raw Aconiti Kusnezoffii Radix (Caowu) and Chebulae Fructus- (Hezi-) Processed Caowu by UPLC-MS/MS

Table 6

Recoveries, matrix effect, and stability of the 6 alkaloids ().

Alkaloids	Concentration (ng/mL)	Extraction recovery (%)	R.S.D. (%)	Matrix effect (%)	R.S.D. (%)	Stability (12 h at 4°C, %)	R.S.D. (%)
AC	0.1	97.11	1.57	97.65	2.64	95.83	14.42
	50	83.31	7.22	85.00	4.87	93.49	4.40
	400	95.75	6.30	91.42	6.54	88.65	7.54
MA	0.1	97.76	5.63	96.91	4.99	97.17	8.93
	50	86.77	7.48	89.80	9.13	88.66	5.70
	400	82.04	8.27	89.36	5.37	95.54	6.49
HA	0.1	99.09	0.63	98.94	0.75	96.33	14.06
	50	86.07	8.92	87.24	11.96	91.58	9.56
	400	82.20	9.43	86.40	11.18	96.15	7.48
BAC	0.1	99.54	2.58	98.54	2.06	89.83	10.89
	50	97.20	10.67	92.49	8.79	94.91	10.03
	400	98.79	8.00	93.48	6.76	94.14	4.31
BMA	0.1	99.77	0.18	99.80	0.20	100.50	11.24
	50	87.16	11.59	93.33	9.46	97.10	8.89
	400	96.46	10.05	95.21	5.20	98.80	6.86
BHA	0.1	100.42	0.70	100.70	0.63	108.00	12.17
	50	96.35	12.10	99.74	7.09	98.07	9.28
	400	98.74	3.44	98.25	1.65	97.91	1.71