Bone Metastases Pattern in Newly Diagnosed Metastatic Nasopharyngeal Carcinoma: A Real-World Analysis in the SEER Database
Table 2
Multivariable Cox regression for analyzing the prognosis factors for primary NPC with bone metastases.
Subject characteristics
No. of NPC patients with bone metastases
Survival, median (IQR), mo
HR (95% CI)
Overall
Dead (, %)
Age
0-24
11
6 (54.5)
24 (7.903-40.097)
1 (reference)
1.0
25-49
77
47 (61.0)
18 (14.907-21.093)
1.298 (0.501-3.361)
0.591
50-74
129
90 (69.8)
13 (9.617-16.383)
2.095 (0.805-5.448)
0.129
75+
18
15 (83.3)
7 (3.425-10.575)
3.896 (1.291-11.754)
0.016
Gender
Female
46
30 (65.2)
19 (10.596-27.404)
1 (reference)
1.0
Male
189
128 (67.7)
13 (10.739-15.261)
1.386 (0.885-2.171)
0.153
Race
White
96
64 (66.7)
13 (7.163-18.837)
1 (reference)
1.0
Black
32
22 (68.8)
13 (9.317-16.683)
1.260 (0.723-2.195)
0.415
Others
107
72 (67.3)
15 (11.383-18.617)
1.177 (0.805-1.723)
0.400
Marital status
Married
125
85 (68.0)
14 (9.798-18.202)
1 (reference)
1.0
Unmarried
96
62 (64.6)
16 (12.550-19.450)
0.924 (0.644-1.326)
0.668
Unknown
14
11 (78.6)
NA
NA
NA
Insurance status
Insured
125
78 (62.4)
17 (13.007-20.993)
1 (reference)
1.0
Uninsured
94
67 (71.3)
13 (9.003-16.997)
1.338 (0.934-1.915)
0.112
Unknown
16
13 (81.3)
NA
NA
NA
T stage
T0
3
3 (100)
12 (0.000-24.803)
1 (reference)
1.0
T1
38
27 (71.1)
16 (11.842-20.158)
0.475 (0.130-1.727)
0.258
T2
22
14 (63.6)
20 (9.457-30.543)
0.329 (0.084-1.286)
0.110
T3
36
28 (77.8)
15 (10.623-19.377)
0.567 (0.154-2.085)
0.392
T4
69
55 (79.7)
8 (5.829-10.171)
0.699 (0.194-2.518)
0.584
Unknown
66
30 (45.5)
NA
NA
NA
N stage
N0
28
22 (78.6)
12 (0.332-23.668)
1 (reference)
1.0
N1
50
39 (78.0)
13 (9.850-16.150)
1.093 (0.603-1.980)
0.769
N2
57
42 (73.7)
17 (13.379-20.621)
0.919 (0.543-1.555)
0.754
N3
50
39 (78.0)
13 (6.447-19.553)
1.208 (0.669-2.179)
0.531
Unknown
50
16 (32.0)
NA
NA
NA
Liver Met
None
152
91 (59.9)
15 (12.02-17.980)
1 (reference)
1.0
Yes
79
64 (81.0)
13 (9.811-16.189)
1.375 (0.947-1.995)
0.094
Unknown
4
3 (75.0)
NA
NA
NA
Brain Met
None
209
138 (66.0)
15 (12.429-17.571)
1 (reference)
1.0
Yes
20
15 (75.0)
5 (0.772-9.228)
1.399 (0.771-2.540)
0.270
Unknown
6
5 (83.3)
NA
NA
NA
Lung Met
None
171
110 (64.3)
15 (12.048-17.952)
1 (reference)
1.0
Yes
59
45 (76.3)
13 (6.425-19.575)
1.361 (0.920-2.014)
0.123
Unknown
5
3 (60.0)
NA
NA
NA
Sequence number
One primary only
212
138 (65.1)
15 (12.305-17.695)
1 (reference)
1.0
Others
23
20 (87.0)
7 (0.000-15.307)
1.868 (1.061-3.287)
0.030
All factors with unknown data were removed from the Cox and Kaplan–Meier model. NPC: nasopharyngeal carcinoma; IQR: interquartile range; mo: months; Met: metastases; Surg: surgical treatments; NA: not available.
