OSCC Exosomes Regulate miR-210-3p Targeting EFNA3 to Promote Oral Cancer Angiogenesis through the PI3K/AKT Pathway

Figure 5

EphrinA3 regulated migration and proliferation in HUVECs by activating the PI3K/AKT pathway. (a, b) Western blot showed that after transfection with si-EphrinA3, the p-AKT/total AKT rate in HUVECs was increased. MK2206 could reduce the phosphorylation of AKT. (c, d) The promotion of HUVEC migration and proliferation by downregulation of ephrinA3 was blocked by MK2206. (e, f) The p-AKT/total AKT rate was declined when ephrinA3 was upregulated by lentivirus. SC79 could promote the phosphorylation of AKT. (g, h) The suppression on HUVEC migration and proliferation as a result of the upregulation of ephrinA3 was inhibited by SC79.

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