Research Article

Clinical Features of COVID-19 Patients with Different Outcomes in Wuhan: A Retrospective Observational Study

Table 2

General laboratory findings of COVID-19 patients on admission to the hospital.

Median (IQR)All ()Nonsurviving ()Surviving () value

Routine blood parameters a
 White blood cell count, ×109/L5.58 (4.22, 7.76)7.95 (5.42, 12.12)5.03 (3.98, 6.35)<0.001
 <3.5, No. (%)32 (11.2%)9 (8.0%)23 (13.3%)0.107
 >9.5, No. (%)43 (15.1%)39 (34.8%)4 (2.3%)<0.001
 Neutrophil count, ×109/L3.89 (2.50, 6.38)6.67 (4.23, 10.59)2.92 (2.19, 4.38)<0.001
 Lymphocyte count, ×109/L0.99 (0.64, 1.44)0.62 (0.41, 0.87)1.34 (0.96, 1.63)<0.001
 <1.1, No. (%)154 (54.0%)97 (86.6%)57 (32.9%)<0.001
 Platelet count, ×109/L195 (148, 249)171.5 (117.5, 214.3)214 (168, 273)<0.001
 <125, No. (%)40 (14.2%)33 (29.5%)7 (4.0%)<0.001
 >350, No. (%)17 (6.0%)1 (0.9%)16 (9.2%)0.004
 Red blood cell count, ×1010/L4.10 (3.69, 4.51)4.03 (3.65, 4.48)4.15 (3.72, 4.52)0.148
Liver function b
 Alanine aminotransferase, U/L24 (16, 40)24 (18, 40)24 (16, 40)0.511
 >150, No. (%)6 (2.1%)2 (1.8%)4 (2.3%)0.778
 Aspartate aminotransferase, U/L29 (21, 43)39 (28, 59)25 (20, 34)<0.001
 >120, No. (%)7 (2.5%)4 (3.7%)3 (1.7%)0.315
 Total bilirubin, μmol/L c11.4 (8.3, 16.2)12.8 (8.6, 19.6)10.7 (8, 14.3)0.001
 Direct bilirubin, μmol/L c4.1 (3, 5.88)5.3 (3.4, 8.57)3.55 (2.78, 4.75)<0.001
 Total protein, g/L c61.1 (57.2, 64.8)58.7 (54.9, 62.3)62.4 (59, 65.9)<0.001
 Albumin, g/L c36.5 (33.0, 39.8)33.3 (30.9, 36.4)38.5 (35.3, 41.7)<0.001
Kidney function d
 Creatinine, μmol/L61 (51, 76)72.5 (55, 99.5)57.5 (48.8, 68.3)<0.001
 Increase, No. (%)55 (19.5%)48 (43.6%)7 (4.1%)<0.001
 Blood urea nitrogen, nmol/L4.88 (3.8, 7.2)7.62 (5.42, 13.22)4.1 (3.44, 5.0)<0.001
 Uric acid, μmol/L257.5 (208, 351.5)267 (182.3, 395)254 (214.8, 323.3)0.405
 Increase, No. (%)60 (21.3%)38 (34.5%)22 (12.7%)<0.001
 Estimated glomerular filtration rate, mL/min98.9 (82.3, 112.5)84.0 (52.5, 97.0)103.9 (96.2, 116.9)<0.001
 ≤90, No. (%)90 (31.9%)64 (58.2%)26 (15.1%)<0.001
Injury of cardiac and skeletal muscles
 Creatine kinase, U/L e68 (43, 112)97.5 (57.8, 236)57 (39, 88.5)<0.001
 >310, No. (%)28 (9.8%)23 (20.9%)5 (3.0%)<0.001
 Creatine kinase-myocardial isoenzyme mb, ng/mL f1.19 (0.64, 2.56)0.82 (0.56, 1.22)0.86 (0.57, 1.21)<0.001
 >5, No. (%)15 (6.9%)15 (14.8%)0 (0)<0.001
 Lactate dehydrogenase, U/L g275 (202, 427)473.5 (341, 612)222.5 (188, 283.3)<0.001
 >250, No. (%)159 (57.4%)95 (85.6%)64 (38.6%)<0.001
 Myoglobin, μg/L h57.6 (30.8, 116.4)106.1 (68.6, 334.8)34.6 (23.4, 52.5)<0.001
 >110, No. (%)58 (27.2%)50 (49.5%)8 (7.1%)<0.001
 Hypersensitive troponin I, ng/mL i0.007 (0.006, 0.046)0.044 (0.015, 0.131)0.044 (0.015, 0.131)<0.001
 >0.0796, No. (%)36 (16.7%)36 (35.0%)0 (0%)<0.001
Arterial blood gas analysis j
 Blood pH7.42 (7.36, 7.46)7.42 (7.35, 7.46)7.41 (7.38, 7.45)0.782
 <7.35, No. (%)30 (17.8%)23 (23.7%)7 (9.7%)0.019
 >7.45, No. (%)56 (33.1%)37 (38.1%)19 (26.3%)0.108
 Arterial oxygen saturation, %94 (88, 97)89 (80, 95)97 (95, 98)<0.001
 <95%, No. (%)89 (52.7%)72 (74.2%)17 (23.6%)<0.001
 Arterial partial pressure of oxygen, mmHg73 (54, 93)57 (45, 75)87 (74, 111)<0.001
 <60 mmHg, No. (%)59 (34.9%)53 (54.6%)6 (8.3%)<0.001
 Arterial partial pressure of carbon dioxide, mmHg40 (35, 45)37 (33, 43)42 (38, 45.3)<0.001
 <35 mmHg, No. (%)40 (23.6%)35 (36.1%)5 (6.9%)<0.001
 >45 mmHg, No. (%)45 (26.6%)20 (20.6%)25 (34.7%)0.064
 Lactic acid, mmol/L k2.3 (1.7, 3.2)2.4 (1.8,3.4)2.2 (1.55, 2.9)0.063
Electrolytes l
 K+, mmol/L3.89 (3.5, 4.21)3.8 (3.4, 4.12)3.91 (3.56, 4.25)0.202
 Na+, mmol/L139 (137, 142)139 (135, 141.6)140 (137, 142)0.022
 Cl-, mmol/L m106 (102.9, 108.3)105.9 (101.6, 109.5)106 (103.4,107.7)0.610
Coagulation function
 Prothrombin time activity, % n81.7 (72.6, 91.4)74.9 (64.1, 85.4)78.85 (68.4, 89.03)<0.001
 Activated partial thromboplastin time, s o28.9 (26.3, 31.5)29.5 (27.7, 32.9)27.95 (25.4, 30.78)<0.001
 D-dimer, μmol/L o1.02 (0.48, 3.69)2.82 (0.91, 12.9)0.66 (0.31, 1.36)<0.001

The total number of patients with available data: a, ; b, ; c, ; d, ; e, ; f, ; g, ; h, ; i, ; j, ; k, ; l, ; m, ; n, ; o, .